Introduction : Many research on Garcinia cambogia are been publise to establish its weightloss ability by slowing down production of fat and the body to metabolise it more efficiently.
STUDY: When Garcinia extract and insulin were added simultaneously, the accumulation of lipid droplets was inhibited and the peak droplet area shifted to become smaller (10-20 microm). The activities of glycerophosphate dehydrogenase, a marker of adipose differentiation, were not significantly inhibited by the Garcinia extract.
CONCLUSION: These findings suggest that the Garcinia extract inhibits lipid droplet accumulation in fat cells without affecting adipose conversion.
Physico-chemical properties of a novel (-)-hydroxycitric acid extract derived from Garcinia Cambogia and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days.
Mol Cell Biochem. 2004 May;260(1-2):171-86.
RESULTS: The findings show that 90 day treatment of HCA-SX results in a reduction in body weight, and does not cause any changes in major organs or in hematology, clinical chemistry, and histopathology.
Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement.
Gene Expr. 2004;11(5-6):251-62.
CONCLUSION: Under the current experimental conditions, HCA-SX proved to be effective in restricting body weight gain in adult rats. Functional characterization of HCA-SX-sensitive genes revealed that upregulation of genes encoding serotonin receptors represent a distinct effect of dietary HCA-SX supplementation.
Effect of Garcinia cambogia extract on serum leptin and insulin in mice.
Fitoterapia. 2003 Apr;74(3):267-73.
In this study we examined the effects of 3.3% Garcinia cambogia extract on 10% sucrose loading in mice for 4 weeks. Treatment was found to have no effect on body weight, fat pad weight or serum glucose level. On the other hand, serum total cholesterol, triglycerides, NEFA were observed. Levels of serum insulin and leptin, as well as the leptin/WAT ratio, were lower in the treated mice than in the control.
CONCLUSION: The findings suggested that G. cambogia extract efficiently improved glucose metabolism and displayed leptin-like activity.
Effects of (-)-hydroxycitric acid on appetitive variables.
Mattes RD, Bormann L. Purdue University, 212 Stone Hall, West Lafayette, IN 47907-1264, USA.
Physiol Behav. 2000 Oct 1-15;71(1-2):87-94.
(-)-Hydroxycitric acid (HCA) reportedly promotes weight loss, in part, through suppression of hunger. However, this mechanism has never been evaluated in humans in a controlled study. No effects of the HCA were observed on appetitive variables. The active treatment group did not exhibit better dietary compliance or significant correlations between appetitive variables and energy intake or weight change. This study does not support a satiety effect of HCA.
1998 Garcinia article in JAMA
Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial.
Heymsfield SB. besity Research Center, St Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.
CONCLUSION: Garcinia cambogia failed to produce significant weight loss and fat mass loss beyond that observed with placebo.
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